Speakers: Maria Chernigovskaya, University of Oslo and Milena Pavlović, University of OsloĪdaptive immune receptor repertoires (AIRRs) capture past and present immune responses and therefore represent a powerful resource for developing diagnostics and therapeutics. Machine learning for the analysis of adaptive immune receptors and repertoires Technologies, challenges, and applications of immune repertoire sequencing ENPICOM 2020. Oude Lohuis et al, High-throughput Sequencing Technologies are Revolutionising Antibody Discovery IBI, 2021. Arnaout et al, The Future of Blood Testing Is the Immunome Front Imm, 2021. By integrating both wet- and dry-lab development and testing, we provide a robust Rep-Seq quantification solution that makes use of the latest developments in genomics, bioinformatics, and drug development. By designing and including spike-ins in pilot sequencing runs, we are able to better assess the characteristics of our Rep-Seq assay. Furthermore, ENPICOM teamed up with Viroclinics/DDL (a Cerba company) to set up a reliable and robust high-quality Rep-Seq method. To validate sequence processing and analysis software, we make use of a simulation framework that takes in an AIRR-compatible repertoire and outputs highly realistic HTS validation data. Given the biological characteristics of the adaptive immune repertoire, important conditions for developing a high-quality Rep-Seq assay include: well-curated germline databases, high-quality sample prep and sequencing, and rock-solid processing software. In this webinar, we describe our journey of setting up a validated Rep-Seq assay for BCR/Antibodies. For antibody discovery, repertoire sequencing has become an indispensable technology capable of generating vast pools of data from which to identify and characterize the best candidates using tools such as IGX Platform. Lorenzo Fanchi, Team Lead Product Management at ENPICOMĪdaptive immune repertoire sequencing (‘Rep-Seq’) is increasingly being used to evaluate the immune system, interventions targeting the immune system (such as vaccination), and immune-derived therapeutics (e.g., immunotherapy and antibodies). Henk-Jan van den Ham, Research Team Leader, and Dr. Setting up Rep-Seq for antibodies: There and back again Want more content on adaptive immune receptors or antibody research and development? Nearly 50 webinars are currently available here. Upcoming AIRR Community Webinars New webinars are coming soon! Meeting Report: The Diagnostic Landscape for COVID-19Īll Antibody Society webinars are open access, and can be viewed for free.Ĭheck out the AIRR Community YouTube Channel for more recorded talks related to this promising field of science.Guide to “Coronavirus in the Crosshairs”.Snakebite antivenoms: Global challenges and progress toward recombinant antibody therapeutics.Antibodies in late-stage clinical studies.Antibody therapeutics approved or in regulatory review in the EU or US.
Huston Antibody Science Talent Award Recipient AIRR Community Meeting IV: “Bridging the Gaps”.AIRR Community Special Event: “Response to COVID-19”.AIRR-seq Biological Standards and Workflows.AIRR Community Meeting V: “Zooming in to the AIRR Community”.AIRR Community Meeting VI: “Exploring New Frontiers”.AIRR Community Special Event 2023 – Zooming in to the Community II.AIRR Community Meeting VII – Learnings and Perspectives.Scientific Advisors, Antibody Engineering & Therapeutics Europe.Antibody Engineering & Therapeutics Europe 2023.2018 Antibody Engineering & Therapeutics.2019 Antibody Engineering & Therapeutics.2020 Antibody Engineering & Therapeutics.2022 Antibody Engineering & Therapeutics.Antibody Engineering & Therapeutics (US) 2023.Emerging Immunotherapeutics for Ovarian Cancer Symposium.Emerging Cancer Therapies Leveraging Gamma-Delta Effector T cells Symposium.Biopharmaceutical Informatics Symposium.Harnessing Cytokines for Cancer Immunotherapy Symposium.Computational Antibody Discovery Symposium Participants.Computational Antibody Discovery: State of the Art.AIRR Community Working Groups & Subcommittees.
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